The 32-year-old Swiss will try and stop Rafael Nadal becoming the first player in the professional era to win the same Grand Slam 10 times.
Roger Federer suffered a shock 3-6, 6-3, 7-6(4) defeat to Australian wildcard Thanasi Kokkinakis on Saturday that will cost the Swiss his world number one ranking and leaves the Miami men's tournament wide open.
Earlier, Ukraine took a 2-0 lead over Japan as world number five Elina Svitolina took the first point of the Billie Jean King Cup era.
Austria's Dominic Thiem strained every sinew trying to cling on to the 32-year-old Spaniard and at times even gained a precarious foothold in his first Grand Slam final.
Slovakia's Dominika Cibulkova stunned top seed Agniezka Radwanska and then trounced Monica Puig to reach the Aegon International at Eastbourne on Friday.
Images from Day 9 of the 2021 French Open at Roland Garros in Paris on Monday.
World number ones Novak Djokovic and Serena Williams will feel like they are working overtime on Friday when organisers cram all four semi-finals into a single session to try and ensure a rain-ravaged tournament ends on schedule.
Rafael Nadal is one win away from a fifth title since returning from injury after the Spanish World No 5 thumped compatriot Pablo Andujar 6-0, 6-4 on Saturday to reach the Madrid Open final.
Alize Cornet fought tooth and nail but the local favourite's French Open run came to an end when she was knocked out 6-2, 7-6(9) in the fourth round by Ukrainian 19th seed Elina Svitolina on Sunday.
Two-time Grand Slam winner Victoria Azarenka crashed out of the French Open in the first round losing 5-7, 5-7 to Katerina Siniakova on Monday, playing only her fifth tournament of the year after a legal battle over the custody of her son.
The two great rivals meet at Roland Garros for the first time in eight years in Friday's tie.
Flushing Meadows semi-finalist Vandeweghe will take on the winner of the contest between fifth seed Karolina Pliskova and Estonia's Anett Kontaveit in Sunday's final.
Rafael Nadal made short work of his great rival Roger Federer to win the Italian Open, his sixth trophy of the year, 6-1, 6-3 on Sunday.
Former world number one Novak Djokovic suffered a surprise second-round exit at the Barcelona Open when the Serb was beaten 6-2, 1-6, 6-3 by world number 140 Martin Klizan on Wednesday.
A rusty Venus Williams was blown away 6-3, 6-2 by rising British left-hander Laura Robson at the Rome Masters tennis on Monday.
World No 1 and top seed Serena Williams racked up the 50th title of her 18-year career when she thumped Maria Sharapova 6-1, 6-4 to defend her Madrid Open crown on Sunday.
Images from Day 2 of the French Open matches played at Roland Garros on Monday
The yellowing obituaries are looking premature as serve-and-volley tennis creeps, with a few tweaks, towards a renaissance of sorts.
Rewarding as it was for Rafael Nadal to become the only player to win the same Grand Slam 12 times by chalking up his dozen at last month's French Open, the Spaniard arrived at Wimbledon this year like a man on a mission. In the end, however, it became mission impossible as he lost to inspired Roger Federer in Friday's blockbuster semi-final.
The trick-shots, underarm serves and tirades at spectators are all part of the theatre, and the 'what will he do next?' lure puts bums on seats, in much the same way John Daly still draws a crowd in golf.
Images from Day 6 of the 2021 French Open at Roland Garros in Paris on Friday.
Rafael Nadal had taken anti-inflammatories and undergone intensive physiotherapy to alleviate a lower back problem and still planned to compete in Buenos Aires next month, his spokesman said on Wednesday.
There was only a scattering of fans inside the stadium as Sharapova took to the court on Wednesday, but after getting into her stride she overpowered the 91st-ranked Diatchenko.
World No 1 Novak Djokovic, second seed Andy Murray and three-time champion Rafael Nadal were all cheered into the quarter-finals of the Rogers Cup on Thursday.
'You can't be frustrated all the time because the neighbour has a bigger house than you, or a bigger TV or better garden. That's not the way that I see the life, you know'
Novak Djokovic, Petra Kvitova and Andy Murray were among the top players who eased into the last 16 of the French Open on Saturday.
Bencic broke Aiava at love to open the match, one of the six break points she converted, and was never really tested as the 18-year-old Australian made 24 unforced errors.
David Goffin and Steve Darcis staged a thrilling comeback on Sunday to take Belgium into their second Davis Cup final in three years with a 3-2 victory over Australia.
Images from Day 7 of the 2021 French Open at Roland Garros in Paris on Saturday.
Nadal paid tribute to his uncle and coach Toni after winning a record-extending 10th French Open title on Sunday.
Rafa Nadal suffered his first claycourt defeat in 23 matches on Thursday and threatened to boycott next year's Madrid Open if officials did not ditch the blue clay that players have labelled 'too slippery' and only fit for 'smurfs (to) play on'.
The 30-year-old is the first German woman to win Wimbledon since Steffi Graf in 1996.
Novak Djokovic marked his return to Serbia, after being stranded in the Spanish resort of Marbella for two months due to the coronavirus lockdown, by announcing that he has organised an event which will be contested across the Balkans. When the world number one had travelled to Marbella with his family in mid-March to visit his younger brother Marko, he had no idea it would be another two months before he could return to his homeland on Sunday.
The British number one will play Croatian Donna Vekic, 7-6(5), 3-6, 7-6(4) victor over Czech Lucie Safarova in the day's second semi-final, in the climax to the Wimbledon warm-up tournament on Sunday.
Defending champion Andy Murray eased into the Wimbledon quarter-finals for the 10th successive year with a 7-6(1), 6-4, 6-4 victory over Benoit Paire on Monday.
World number one Novak Djokovic turned the page on his contentious US Open exit and began his claycourt season with a convincing 6-3, 6-2 victory over wildcard Salvatore Caruso in the second round of the Italian Open.
Images from Day 7 of the 2021 US Open in New York on Sunday.
Roger Federer moved a step closer to a record-equalling 20th Masters title when he thumped Janko Tipsarevic 6-2 6-3 at the Madrid Open on Saturday to set up a final showdown with Tomas Berdych.
A summary of Sunday's matches at the French Open.
Images from Day 3 of the French Open matches played at Roland Garros on Tuesday
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